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Synlett
DOI: 10.1055/a-2640-2542
letter

[AcMIm]Cl-Catalyzed One-Pot Multicomponent Synthesis of Pyran Chromene Derivatives

Dhaneshwar Prasad
1   Department of Chemistry, Guru Ghasidas Vishwavidyalaya, Guru Ghasidas Vishwavidyalaya, Bilaspur, India (Ringgold ID: RIN28718)
,
Subhash Banerjee 
2   Department of Chemistry, Guru Ghasidas University, Bilaspur, India (Ringgold ID: RIN28718)
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A sustainable one-pot multicomponent synthesis of dihydropyrano[3,2-c]chromenes and 2-aminochromenes was developed using [AcMIm]Cl, a task-specific acidic ionic liquid catalyst, under mild, solvent-free conditions. The present protocol affords dihydropyrano[3,2-c]chromenes in excellent yields (93-99%) with a short reaction time (4-5 minutes), and comparable efficiency was observed for the 2-aminochromenes (90-92%). The bifunctional [AcMIm]Cl bears an acidic carboxyl (COOH) and a basic imidazilum nitrogen, which act synergistically to activate both the aldehyde carbonyl and the malononitrile C-H bond, thereby accelerating the reaction. The major advantages of this method include simple workup: no volatile organic solvent, and the solid products were purified by recrystallization from hot ethanol without chromatography. These features render the present method environmentally benign and economically advantageous than conventional approaches.



Publication History

Received: 30 April 2025

Accepted after revision: 19 June 2025

Accepted Manuscript online:
20 June 2025

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